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Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.
Black, Joshua C; Atabakhsh, Elnaz; Kim, Jaegil; Biette, Kelly M; Van Rechem, Capucine; Ladd, Brendon; Burrowes, Paul D; Donado, Carlos; Mattoo, Hamid; Kleinstiver, Benjamin P; Song, Bing; Andriani, Grasiella; Joung, J Keith; Iliopoulos, Othon; Montagna, Cristina; Pillai, Shiv; Getz, Gad; Whetstine, Johnathan R.
Affiliation
  • Black JC; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA;
  • Atabakhsh E; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA;
  • Kim J; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA;
  • Biette KM; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA;
  • Van Rechem C; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA;
  • Ladd B; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA;
  • Burrowes PD; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA;
  • Donado C; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA;
  • Mattoo H; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA;
  • Kleinstiver BP; Massachusetts General Hospital Cancer Center, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129, USA; Massachusetts General Hospital Center for Computational and Integrative Biology, Charlestown, Massachusetts 02129, USA;
  • Song B; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA;
  • Andriani G; Department of Genetics, Pathology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461, USA;
  • Joung JK; Massachusetts General Hospital Cancer Center, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129, USA; Massachusetts General Hospital Center for Computational and Integrative Biology, Charlestown, Massachusetts 02129, USA;
  • Iliopoulos O; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA; Department of Medicine, Division of Hematology-Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
  • Montagna C; Department of Genetics, Pathology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461, USA;
  • Pillai S; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA;
  • Getz G; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA; Massachusetts General Hospital Cancer Center, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129, USA;
  • Whetstine JR; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA; jwhetstine@hms.harvard.edu.
Genes Dev ; 29(10): 1018-31, 2015 May 15.
Article in En | MEDLINE | ID: mdl-25995187
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Full text: 1 Database: MEDLINE Main subject: Cell Hypoxia / Gene Expression Regulation / DNA Copy Number Variations Limits: Animals / Humans Language: En Year: 2015 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Cell Hypoxia / Gene Expression Regulation / DNA Copy Number Variations Limits: Animals / Humans Language: En Year: 2015 Type: Article