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Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.
Ezzat, Kariem; Aoki, Yoshitsugu; Koo, Taeyoung; McClorey, Graham; Benner, Leif; Coenen-Stass, Anna; O'Donovan, Liz; Lehto, Taavi; Garcia-Guerra, Antonio; Nordin, Joel; Saleh, Amer F; Behlke, Mark; Morris, John; Goyenvalle, Aurelie; Dugovic, Branislav; Leumann, Christian; Gordon, Siamon; Gait, Michael J; El-Andaloussi, Samir; Wood, Matthew J A.
Affiliation
  • Ezzat K; †Department of Physiology, Anatomy, and Genetics, University of Oxford, OX13QX, Oxford, United Kingdom.
  • Aoki Y; †Department of Physiology, Anatomy, and Genetics, University of Oxford, OX13QX, Oxford, United Kingdom.
  • Koo T; ●Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo 187-8551, Japan.
  • McClorey G; †Department of Physiology, Anatomy, and Genetics, University of Oxford, OX13QX, Oxford, United Kingdom.
  • Benner L; ‡Center for Genome Engineering, Institute for Basic Science, Seoul 151-747, South Korea.
  • Coenen-Stass A; §Functional Genomics, University of Science and Technology, Daejeon 305-338, South Korea.
  • O'Donovan L; †Department of Physiology, Anatomy, and Genetics, University of Oxford, OX13QX, Oxford, United Kingdom.
  • Lehto T; †Department of Physiology, Anatomy, and Genetics, University of Oxford, OX13QX, Oxford, United Kingdom.
  • Garcia-Guerra A; †Department of Physiology, Anatomy, and Genetics, University of Oxford, OX13QX, Oxford, United Kingdom.
  • Nordin J; ∥Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
  • Saleh AF; ⊥Department of Laboratory Medicine, Karolinska Institute, Stockholm SE-171 77, Sweden.
  • Behlke M; #Clarendon Laboratory, Department of Physics, University of Oxford, OX13PU, Oxford, United Kingdom.
  • Morris J; ⊥Department of Laboratory Medicine, Karolinska Institute, Stockholm SE-171 77, Sweden.
  • Goyenvalle A; ∥Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
  • Dugovic B; ∇Integrated DNA Technologies (IDT), Coralville, Iowa 55241, United States.
  • Leumann C; †Department of Physiology, Anatomy, and Genetics, University of Oxford, OX13QX, Oxford, United Kingdom.
  • Gordon S; ○Université de Versailles Saint Quentin, Montigny le Bretonneux 78180, France.
  • Gait MJ; ◆Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland.
  • El-Andaloussi S; ◆Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland.
  • Wood MJ; ¶Sir William Dunn School of Pathology, University of Oxford, OX1 3RE, Oxford, United Kingdom.
Nano Lett ; 15(7): 4364-73, 2015 Jul 08.
Article in En | MEDLINE | ID: mdl-26042553
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Full text: 1 Database: MEDLINE Main subject: Oligonucleotides, Antisense / Scavenger Receptors, Class A / Nanoparticles Limits: Animals Language: En Year: 2015 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Oligonucleotides, Antisense / Scavenger Receptors, Class A / Nanoparticles Limits: Animals Language: En Year: 2015 Type: Article