Vitamin D toxicity resulting from overzealous correction of vitamin D deficiency.
Clin Endocrinol (Oxf)
; 83(3): 327-31, 2015 Sep.
Article
in En
| MEDLINE
| ID: mdl-26053339
ABSTRACT
BACKGROUND:
Vitamin D toxicity, often considered rare, can be life-threatening and associated with substantial morbidity, if not identified promptly.OBJECTIVE:
To describe clinical and biochemical features, risk factors and management of patients with vitamin D toxicity seen between January 2011 and January 2013.METHODOLOGY:
Patients presenting with vitamin D toxicity, between January 2011 and January 2013, at single tertiary care centre in Delhi-NCR, India, were included. Evaluation included detailed clinical history and biochemical tests including serum calcium, phosphorus, creatinine, intact parathyroid hormone and 25-hydroxyvitamin D (25(OH)D).RESULTS:
Sixteen patients with vitamin D toxicity could be identified. Clinical manifestations included nausea, vomiting, altered sensorium, constipation, pancreatitis, acute kidney injury and weight loss. Median (range) age was 64·5 (42-86) years. Median (range) serum 25(OH)D level and median (range) serum total serum calcium level were 371 (175-1161) ng/ml and 13·0 (11·1-15·7) mg/dl, respectively. Overdose of vitamin D caused by prescription of mega-doses of vitamin D was the cause of vitamin D toxicity in all cases. Median (range) cumulative vitamin D dose was 3,600,000 (2,220,000-6,360,000) IU.CONCLUSION:
Our data demonstrate an emergence of vitamin D toxicity as an increasingly common cause of symptomatic hypercalcaemia. Irrational use of vitamin D in mega-doses resulted in vitamin D toxicity in all cases. Awareness among healthcare providers regarding the toxic potential of high doses of vitamin D and cautious use of vitamin D supplements is the key to prevent this condition.
Full text:
1
Database:
MEDLINE
Main subject:
Vitamin D
/
Vitamin D Deficiency
/
Dietary Supplements
/
Drug Overdose
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Humans
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Year:
2015
Type:
Article