Acute corneal toxicity of latanoprost with different preservatives.
Cutan Ocul Toxicol
; 35(2): 120-5, 2016.
Article
in En
| MEDLINE
| ID: mdl-26113030
ABSTRACT
PURPOSE:
To investigate the corneal toxicity of Xalatan and three latanoprost generics using transepithelial electrical resistance (TER) and scanning electron microscopy (SEM).METHODS:
Corneal TER changes after a 60-s exposure to Xalatan (latanoprost 0.005% preserved with 0.02% BAC), and latanoprost generics (Latanoprost PF BAC free, Latanoprost Nitten SB containing sodium benzoate and Latanoprost Towa containing 0.01% BAC with sodium chloride polysorbate 80 as additive) were measured in living rabbits. Corneal damage was also examined by SEM. Hank's balanced salt solution (HBSS) was used as a control.RESULTS:
There was a significant decrease in the corneal TER after exposure of the cornea to Xalatan (p < 0.01) and all latanoprost generics (p < 0.01 Latanoprost PF, p < 0.05 Latanoprost Nitten SB, Latanoprost Towa) as compared to HBSS. All latanoprost generics showed less TER decrease in the corneal TER as compared to Xalatan (p < 0.01). SEM revealed that superficial cells of Xalatan-treated corneas were damaged and exhibited degenerated microvilli. Conversely, the superficial cells of corneas exposed to HBSS or all latanoprost generics appeared normal and had normal microvilli under SEM examinations.CONCLUSION:
The corneal toxicity of Xalatan is greater than that of latanoprost generics. Xalatan contains 0.02% BAC, which may be responsible for the corneal toxicity.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Ophthalmic Solutions
/
Preservatives, Pharmaceutical
/
Prostaglandins F, Synthetic
/
Benzalkonium Compounds
/
Drugs, Generic
/
Epithelium, Corneal
Limits:
Animals
Language:
En
Year:
2016
Type:
Article