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Riboswitch-mediated Attenuation of Transgene Cytotoxicity Increases Adeno-associated Virus Vector Yields in HEK-293 Cells.
Strobel, Benjamin; Klauser, Benedikt; Hartig, Jörg S; Lamla, Thorsten; Gantner, Florian; Kreuz, Sebastian.
Affiliation
  • Strobel B; Target Discovery Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.
  • Klauser B; Department of Chemistry, University of Konstanz, Konstanz, Germany.
  • Hartig JS; Department of Chemistry, University of Konstanz, Konstanz, Germany.
  • Lamla T; Target Discovery Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.
  • Gantner F; Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.
  • Kreuz S; Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.
Mol Ther ; 23(10): 1582-91, 2015 Oct.
Article in En | MEDLINE | ID: mdl-26137851
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Full text: 1 Database: MEDLINE Main subject: Virus Replication / Dependovirus / Transgenes / Riboswitch / Genetic Vectors Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Year: 2015 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Virus Replication / Dependovirus / Transgenes / Riboswitch / Genetic Vectors Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Year: 2015 Type: Article