Estimation of divergence from Hardy-Weinberg form.
Twin Res Hum Genet
; 18(4): 399-405, 2015 Aug.
Article
in En
| MEDLINE
| ID: mdl-26138075
ABSTRACT
The HardyWeinberg (HW) principle explains how random mating (RM) can produce and maintain a population in equilibrium, that is, with constant genotypic proportions. When proportions diverge from HW form, it is of interest to estimate the fixation index F, which reflects the degree of divergence. Starting from a sample of genotypic counts, a mixed procedure gives first the orthodox estimate of gene frequency q and then a Bayesian estimate of F, based on a credible prior distribution of F, which is described here.
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Database:
MEDLINE
Main subject:
Bayes Theorem
/
Genetics, Population
/
Models, Genetic
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Year:
2015
Type:
Article