Long-term Remission in a Female With Multiple Relapsed Juvenile Granulosa Cell Tumor.
J Pediatr Hematol Oncol
; 37(8): e486-9, 2015 Nov.
Article
in En
| MEDLINE
| ID: mdl-26165406
ABSTRACT
A 4 ½-year-old female was diagnosed with ovarian juvenile granulosa cell tumor stage IA. After complete tumor resection she received 4 courses of chemotherapy due to unfavorable histopathologic features (high mitotic index, high microvessel density, blood vessel invasion). One year after diagnosis, she experienced paraaortic lymph node relapse treated with surgery, local radiotherapy, and conventional and high-dose chemotherapy. A second, paratracheal lymph node relapse 7 months later necessitated surgical removal and radiotherapy. Subsequently an adjuvant antiangiogenesis-based treatment including paclitaxel, bevacizumab, thalidomide, and pegylated interferon was initiated and continued for 2 years. The female is now in third complete remission 6 years after second relapse.
Full text:
1
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Salvage Therapy
/
Granulosa Cell Tumor
Limits:
Child, preschool
/
Female
/
Humans
Language:
En
Year:
2015
Type:
Article