Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study.

Collepardo-Guevara, Rosana; Portella, Guillem; Vendruscolo, Michele; Frenkel, Daan; Schlick, Tamar; Orozco, Modesto

Collepardo-Guevara, Rosana; Portella, Guillem; Vendruscolo, Michele; Frenkel, Daan; Schlick, Tamar; Orozco, Modesto.

Affiliation

Collepardo-Guevara R; Chemistry Department, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW United Kingdom.
Portella G; Joint BSC-CRG-IRB Programme on Computational Biology, Institute for Research in Biomedicine, Baldiri i Reixac 19, 08028, Barcelona, Spain.
Vendruscolo M; Chemistry Department, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW United Kingdom.
Frenkel D; Joint BSC-CRG-IRB Programme on Computational Biology, Institute for Research in Biomedicine, Baldiri i Reixac 19, 08028, Barcelona, Spain.
Schlick T; Chemistry Department, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW United Kingdom.
Orozco M; Chemistry Department, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW United Kingdom.

J Am Chem Soc ; 137(32): 10205-15, 2015 Aug 19.

Article in En | MEDLINE | ID: mdl-26192632

Subject(s)

Chromatin/chemistry; Chromatin/genetics; Epigenesis, Genetic; Histones/chemistry; Acetylation; Chromatin/metabolism; Histones/metabolism; Lysine/metabolism; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Monte Carlo Method; Nucleosomes/chemistry; Nucleosomes/metabolism

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Full text: 1 Database: MEDLINE Main subject: Chromatin / Histones / Epigenesis, Genetic Type of study: Health_economic_evaluation Language: En Year: 2015 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Chromatin / Histones / Epigenesis, Genetic Type of study: Health_economic_evaluation Language: En Year: 2015 Type: Article