Optimal design of perturbations for individual two-compartment pharmacokinetic analysis.

Shotwell, Matthew S; Zhou, Minchun; Fissell, William H

Shotwell, Matthew S; Zhou, Minchun; Fissell, William H.

Affiliation

Shotwell MS; a Department of Biostatistics , Vanderbilt University , Nashville , Tennessee , USA.
Zhou M; a Department of Biostatistics , Vanderbilt University , Nashville , Tennessee , USA.
Fissell WH; b Department of Medicine , Vanderbilt University , Nashville , Tennessee , USA.

J Biopharm Stat ; 26(5): 803-15, 2016.

Article in En | MEDLINE | ID: mdl-26247447

Subject(s)

Anti-Bacterial Agents/pharmacokinetics; Renal Dialysis; Administration, Intravenous; Anti-Bacterial Agents/administration & dosage; Humans; Models, Statistical; Monte Carlo Method

Key words

Challenge response; hemodialysis; optimal design; pharmacokinetic; piperacillin; simulation; two-compartment model

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Full text: 1 Database: MEDLINE Main subject: Renal Dialysis / Anti-Bacterial Agents Type of study: Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Year: 2016 Type: Article

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