Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain.

Thompson, Jeremy M; Ji, Guangchen; Neugebauer, Volker

Thompson, Jeremy M; Ji, Guangchen; Neugebauer, Volker.

Affiliation

Thompson JM; Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX, 79430-6592, USA. jeremy.thompson@ttuhsc.edu.
Ji G; Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX, 79430-6592, USA. guangchen.ji@ttuhsc.edu.
Neugebauer V; Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX, 79430-6592, USA. volker.neugebauer@ttuhsc.edu.

Mol Pain ; 11: 51, 2015 Aug 28.

Article in En | MEDLINE | ID: mdl-26311432

Subject(s)

Amygdala/metabolism; Arthritis/drug therapy; Pain/drug therapy; Riluzole/therapeutic use; Small-Conductance Calcium-Activated Potassium Channels/metabolism; Amygdala/drug effects; Animals; Arthritis/complications; Arthritis/metabolism; Arthritis/pathology; Disease Models, Animal; Hindlimb/drug effects; Male; Microdialysis; Pain/complications; Pain/metabolism; Pain/pathology; Rats, Sprague-Dawley; Riluzole/administration & dosage; Riluzole/pharmacology; Stereotaxic Techniques; Vocalization, Animal/drug effects

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Pain / Arthritis / Riluzole / Small-Conductance Calcium-Activated Potassium Channels / Amygdala Limits: Animals Language: En Year: 2015 Type: Article

Fulltext

XML

PubMed Links

Search on Google