Antioxidant and anti-inflammatory properties of 1,2,4-oxadiazole analogs of resveratrol.

Gobec, Martina; Tomasic, Tihomir; Markovic, Tijana; Mlinaric-Rascan, Irena; Dolenc, Marija Sollner; Jakopin, Ziga.

Affiliation

Gobec M; Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI-1000 Ljubljana, Slovenia.
Tomasic T; Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI-1000 Ljubljana, Slovenia.
Markovic T; Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI-1000 Ljubljana, Slovenia.
Mlinaric-Rascan I; Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI-1000 Ljubljana, Slovenia.
Dolenc MS; Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI-1000 Ljubljana, Slovenia.
Jakopin Z; Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI-1000 Ljubljana, Slovenia. Electronic address: ziga.jakopin@ffa.uni-lj.si.

Chem Biol Interact ; 240: 200-7, 2015 Oct 05.

Article in En | MEDLINE | ID: mdl-26335192

Subject(s)

Oxadiazoles/pharmacology; Stilbenes/pharmacology; Anti-Inflammatory Agents/chemistry; Anti-Inflammatory Agents/pharmacology; Antioxidants/chemistry; Antioxidants/pharmacology; Blotting, Western; Cell Line; Cell Survival/drug effects; Enzyme Activation/drug effects; Models, Molecular; Oxadiazoles/chemistry; Protein Serine-Threonine Kinases/antagonists & inhibitors; Protein Serine-Threonine Kinases/metabolism; Reactive Oxygen Species/metabolism; Resveratrol; Stilbenes/chemistry; NF-kappaB-Inducing Kinase

Key words

1,2,4-Oxadiazole; Anti-Inflammatory; Antioxidant; NF-κB inhibition; Resveratrol