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The E3 ubiquitin ligase Asb2ß is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation.
Thottakara, Tilo; Friedrich, Felix W; Reischmann, Silke; Braumann, Simon; Schlossarek, Saskia; Krämer, Elisabeth; Juhr, Denise; Schlüter, Hartmut; van der Velden, Jolanda; Münch, Julia; Patten, Monica; Eschenhagen, Thomas; Moog-Lutz, Christel; Carrier, Lucie.
Affiliation
  • Thottakara T; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany;; University Heart Center Hamburg, Hamburg, Germany;
  • Friedrich FW; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany;. Electronic address: f.friedrich@uke.de.
  • Reischmann S; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany;
  • Braumann S; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany;
  • Schlossarek S; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany;
  • Krämer E; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany;
  • Juhr D; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;
  • Schlüter H; Institute of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;
  • van der Velden J; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands; ICIN-Netherlands Heart Institute, Utrecht, the Netherlands.
  • Münch J; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany;; University Heart Center Hamburg, Hamburg, Germany;
  • Patten M; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany;; University Heart Center Hamburg, Hamburg, Germany;
  • Eschenhagen T; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany;
  • Moog-Lutz C; Institut de Pharmacologie et de Biologie Structurale, CNRS, Toulouse, France;; Université de Toulouse, UPS, Toulouse, France.
  • Carrier L; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany;. Electronic address: l.carrier@uke.de.
J Mol Cell Cardiol ; 87: 214-24, 2015 Oct.
Article in En | MEDLINE | ID: mdl-26343497
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Full text: 1 Database: MEDLINE Main subject: Cardiomyopathy, Hypertrophic / Myocytes, Cardiac / Adaptor Proteins, Signal Transducing / Desmin / Myocardium Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2015 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Cardiomyopathy, Hypertrophic / Myocytes, Cardiac / Adaptor Proteins, Signal Transducing / Desmin / Myocardium Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2015 Type: Article