Impaired T-bet-pSTAT1&#945; and perforin-mediated immune responses in the tumoral region of lung adenocarcinoma.

Andreev, Katerina; Trufa, Denis Iulian; Siegemund, Raphaela; Rieker, Ralf; Hartmann, Arndt; Schmidt, Joachim; Sirbu, Horia; Finotto, Susetta

Impaired T-bet-pSTAT1α and perforin-mediated immune responses in the tumoral region of lung adenocarcinoma.

Andreev, Katerina; Trufa, Denis Iulian; Siegemund, Raphaela; Rieker, Ralf; Hartmann, Arndt; Schmidt, Joachim; Sirbu, Horia; Finotto, Susetta.

Affiliation

Andreev K; Department of Molecular Pneumology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen 91054, Germany.
Trufa DI; Department of Molecular Pneumology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen 91054, Germany.
Siegemund R; Department of Thoracic Surgery, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen 91054, Germany.
Rieker R; Department of Molecular Pneumology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen 91054, Germany.
Hartmann A; Institute of Pathology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen 91054, Germany.
Schmidt J; Institute of Pathology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen 91054, Germany.
Sirbu H; Institute of Anesthesiology, Friedrich-Alexander-University of Erlangen-Nürnberg, 91054, Germany.
Finotto S; Department of Thoracic Surgery, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen 91054, Germany.

Br J Cancer ; 113(6): 902-13, 2015 09 15.

Article in En | MEDLINE | ID: mdl-26348446

Subject(s)

Adenocarcinoma/immunology; Carcinoma, Squamous Cell/immunology; Interferon-Stimulated Gene Factor 3/analysis; Lung Neoplasms/immunology; Neoplasm Proteins/analysis; Perforin/analysis; Adenocarcinoma/therapy; Adult; Aged; Aged, 80 and over; CD8-Positive T-Lymphocytes/immunology; Carcinoma, Non-Small-Cell Lung/immunology; Carcinoma, Non-Small-Cell Lung/therapy; Carcinoma, Squamous Cell/therapy; Cytokines/analysis; Female; Humans; Interferon-Stimulated Gene Factor 3/genetics; Interferon-gamma/analysis; Lung Neoplasms/therapy; Lymphocyte Count; Lymphocytes, Tumor-Infiltrating; Male; Middle Aged; Paraffin Embedding; Programmed Cell Death 1 Receptor/analysis; Protein Isoforms/analysis; RNA, Messenger/analysis; T-Box Domain Proteins/analysis; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Adenocarcinoma / Interferon-Stimulated Gene Factor 3 / Perforin / Lung Neoplasms / Neoplasm Proteins Type of study: Prognostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2015 Type: Article

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