Comparison of common platelet receptors between the chacma baboon (Papio ursinus) and human for use in pre-clinical human-targeted anti-platelet studies.

Janse van Rensburg, Walter J

Janse van Rensburg, Walter J.

Affiliation

Janse van Rensburg WJ; a Department of Haematology and Cell Biology, Faculty of Health Sciences , University of the Free State , Bloemfontein , Free State , South Africa.

Platelets ; 27(4): 322-32, 2016 Jun.

Article in En | MEDLINE | ID: mdl-26559117

Subject(s)

Blood Platelets/drug effects; Blood Platelets/metabolism; Platelet Aggregation Inhibitors/pharmacology; Platelet Membrane Glycoproteins/metabolism; Receptors, Cell Surface/metabolism; Adenosine Diphosphate/pharmacology; Amino Acid Sequence; Amino Acid Substitution; Animals; Arachidonic Acid/pharmacology; Drug Evaluation, Preclinical; Flow Cytometry; Humans; Male; Papio ursinus; Platelet Aggregation/drug effects; Platelet Membrane Glycoproteins/chemistry; Platelet Membrane Glycoproteins/genetics; Receptors, Cell Surface/chemistry; Receptors, Cell Surface/genetics; Receptors, Purinergic P2/chemistry; Receptors, Purinergic P2/genetics; Receptors, Purinergic P2/metabolism; Ristocetin/pharmacology

Key words

Anti-platelet studies; chacma baboon; platelet receptors

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Full text: 1 Database: MEDLINE Main subject: Blood Platelets / Platelet Aggregation Inhibitors / Platelet Membrane Glycoproteins / Receptors, Cell Surface Limits: Animals / Humans / Male Language: En Year: 2016 Type: Article

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