Role of Echinocandins in Fungal Biofilm-Related Disease: Vascular Catheter-Related Infections, Immunomodulation, and Mucosal Surfaces.
Clin Infect Dis
; 61 Suppl 6: S622-9, 2015 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-26567280
ABSTRACT
Biofilm-related infections have become an increasingly important clinical problem. Many of these infections occur in patients with multiple comorbidities or with impaired immunity. Echinocandins (caspofungin, micafungin, and anidulafungin) exert their fungicidal activity by inhibition of the synthesis of the (1â3)-ß-d-glucan. They are active among in vitro and in vivo model systems against a number of Candida species and filamentous fungi in their planktonic and biofilm phenotype. Their superior activity against biofilms poses them in an advantageous position among the antifungal armamentarium. However, additional studies are warranted to expand our knowledge on the role of echinocandins against biofilm-related infections.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Biofilms
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Echinocandins
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Catheter-Related Infections
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Fungi
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Mucous Membrane
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Mycoses
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Antifungal Agents
Limits:
Animals
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Humans
Language:
En
Year:
2015
Type:
Article