Regulatory Forum Opinion Piece*: Retrospective Evaluation of Doses in the 26-week Tg.rasH2 Mice Carcinogenicity Studies: Recommendation to Eliminate High Doses at Maximum Tolerated Dose in Future Studies. A Response to the Counterpoints.

Paranjpe, Madhav G; Denton, Melissa D; Vidmar, Tom J; Elbekai, Reem H

Paranjpe, Madhav G; Denton, Melissa D; Vidmar, Tom J; Elbekai, Reem H.

Affiliation

Paranjpe MG; BioReliance By SAFC, Rockville, Maryland, USA madhav.paranjpe@bioreliance.com.
Denton MD; Virginia Commonwealth University, Richmond, Virginia, USA.
Vidmar TJ; BioSTAT Consultants, Inc., Portage, Michigan, USA.
Elbekai RH; PAREXEL International, Bethesda, Maryland, USA.

Toxicol Pathol ; 44(1): 5-8, 2016 Jan.

Article in En | MEDLINE | ID: mdl-26578636

Subject(s)

Carcinogenicity Tests/methods; Carcinogenicity Tests/standards; Genes, ras; Maximum Tolerated Dose; Mice, Transgenic; Animals; Body Weight; Eating; Female; Male; Mice; Retrospective Studies

Key words

MTD; Tg.rasH2 mice; alternative models in toxicology; carcinogenesis; preclinical research and development; toxicologic pathology; transgenic animals

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Full text: 1 Database: MEDLINE Main subject: Mice, Transgenic / Carcinogenicity Tests / Genes, ras / Maximum Tolerated Dose Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Year: 2016 Type: Article

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