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Study of Subchronic Toxicity of Relatox on Sexually Immature Animals.
Churin, A A; Fomina, T I; Ermolaeva, L A; Vetoshkina, T V; Dubskaya, T Yu; Lamzina, T Yu; Fedorova, E P; Neupokoeva, O V; Nikiforova, A N.
Affiliation
  • Churin AA; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. toxicology_lab@mail.ru.
  • Fomina TI; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Ermolaeva LA; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Vetoshkina TV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Dubskaya TY; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Lamzina TY; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Fedorova EP; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Neupokoeva OV; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Nikiforova AN; Microgen Research-and-Production Center for Medical and Immunobiological Drugs, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med ; 160(1): 53-6, 2015 Nov.
Article in En | MEDLINE | ID: mdl-26593416
ABSTRACT
Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameters, and morphology of the major viscera. In the toxic dose, the drug caused local irritation (inflammation, atrophy, and sclerosis in muscle tissue). Regeneration processes started in muscle tissue 7 days after Relatox withdrawal.
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Full text: 1 Database: MEDLINE Main subject: Paresis / Botulinum Toxins, Type A / Exploratory Behavior / Hemagglutinins / Locomotion Limits: Animals Language: En Year: 2015 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Paresis / Botulinum Toxins, Type A / Exploratory Behavior / Hemagglutinins / Locomotion Limits: Animals Language: En Year: 2015 Type: Article