Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis.

Kim, Ki Mo; Im, A-Rang; Kim, Seung Hyung; Hyun, Jin Won; Chae, Sungwook

Kim, Ki Mo; Im, A-Rang; Kim, Seung Hyung; Hyun, Jin Won; Chae, Sungwook.

Affiliation

Kim KM; KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea.
Im AR; KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea.
Kim SH; Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon, Korea.
Hyun JW; School of Medicine and Institute for Nuclear Science and Technology, Jeju National University, Jeju, Korea.
Chae S; KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea.

Cancer Sci ; 107(2): 181-8, 2016 Feb.

Article in En | MEDLINE | ID: mdl-26595378

Subject(s)

Antineoplastic Agents/pharmacology; Cyclooxygenase 2/biosynthesis; Melanoma, Experimental/pathology; Saponins/pharmacology; Steroids/pharmacology; Animals; Blotting, Western; Cell Line, Tumor; Cell Movement/drug effects; Cyclooxygenase 2 Inhibitors/pharmacology; Dinoprostone/metabolism; Humans; Mice; Mice, Inbred C57BL; NF-kappa B/metabolism; Neoplasm Invasiveness/pathology; RNA, Small Interfering; Receptors, Prostaglandin E/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Transfection

Key words

COX-2; melanoma cells; metastasis; migration; timosaponin AIII

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Full text: 1 Database: MEDLINE Main subject: Saponins / Steroids / Melanoma, Experimental / Cyclooxygenase 2 / Antineoplastic Agents Limits: Animals / Humans Language: En Year: 2016 Type: Article

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