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Biosynthetic engineering and fermentation media development leads to gram-scale production of spliceostatin natural products in Burkholderia sp.
Eustáquio, Alessandra S; Chang, Li-Ping; Steele, Greg L; O Donnell, Christopher J; Koehn, Frank E.
Affiliation
  • Eustáquio AS; Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, USA. Electronic address: ase@uic.edu.
  • Chang LP; Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, USA.
  • Steele GL; Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, USA.
  • O Donnell CJ; Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, USA.
  • Koehn FE; Natural Products Laboratory, Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, CT 06340, USA.
Metab Eng ; 33: 67-75, 2016 Jan.
Article in En | MEDLINE | ID: mdl-26620532
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Full text: 1 Database: MEDLINE Main subject: Pyrans / Burkholderia / Culture Media / Biosynthetic Pathways / Metabolic Engineering Language: En Year: 2016 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Pyrans / Burkholderia / Culture Media / Biosynthetic Pathways / Metabolic Engineering Language: En Year: 2016 Type: Article