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Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.
Chen, Shih-Hsun; Zhang, Youyan; Van Horn, Robert D; Yin, Tinggui; Buchanan, Sean; Yadav, Vipin; Mochalkin, Igor; Wong, Swee Seong; Yue, Yong Gang; Huber, Lysiane; Conti, Ilaria; Henry, James R; Starling, James J; Plowman, Gregory D; Peng, Sheng-Bin.
Affiliation
  • Chen SH; Oncology Research, Eli Lilly and Company, Indianapolis, Indiana.
  • Zhang Y; Oncology Research, Eli Lilly and Company, Indianapolis, Indiana.
  • Van Horn RD; Oncology Research, Eli Lilly and Company, Indianapolis, Indiana.
  • Yin T; Oncology Research, Eli Lilly and Company, Indianapolis, Indiana.
  • Buchanan S; Oncology Research, Eli Lilly and Company, Indianapolis, Indiana.
  • Yadav V; Oncology Research, Eli Lilly and Company, Indianapolis, Indiana.
  • Mochalkin I; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Indianapolis, Indiana.
  • Wong SS; Tailored Therapeutics, Eli Lilly and Company, Indianapolis, Indiana.
  • Yue YG; Tailored Therapeutics, Eli Lilly and Company, Indianapolis, Indiana.
  • Huber L; Oncology Research, Eli Lilly and Company, Indianapolis, Indiana.
  • Conti I; Oncology Business Unit, Eli Lilly and Company, Indianapolis, Indiana.
  • Henry JR; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Indianapolis, Indiana.
  • Starling JJ; Oncology Research, Eli Lilly and Company, Indianapolis, Indiana.
  • Plowman GD; Oncology Research, Eli Lilly and Company, Indianapolis, Indiana.
  • Peng SB; Oncology Research, Eli Lilly and Company, Indianapolis, Indiana. peng_sheng-bin@lilly.com.
Cancer Discov ; 6(3): 300-15, 2016 Mar.
Article in En | MEDLINE | ID: mdl-26732095
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Full text: 1 Database: MEDLINE Main subject: Phenylurea Compounds / Pyrimidines / Gene Deletion / Drug Resistance, Neoplasm / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors / Protein Multimerization / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Year: 2016 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Phenylurea Compounds / Pyrimidines / Gene Deletion / Drug Resistance, Neoplasm / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors / Protein Multimerization / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Year: 2016 Type: Article