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Novel naphtho[2,1-d]oxazole-4,5-diones as NQO1 substrates with improved aqueous solubility: Design, synthesis, and in vivo antitumor evaluation.
Li, Xiang; Bian, Jinlei; Wang, Nan; Qian, Xue; Gu, Jing; Mu, Tong; Fan, Jun; Yang, Xiuwen; Li, Shangzhen; Yang, Tingting; Sun, Haopeng; You, Qidong; Zhang, Xiaojin.
Affiliation
  • Li X; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Department of Pharmaceutical Engineering, China Pharmaceutical University, Nanjing 210009, China.
  • Bian J; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Wang N; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Qian X; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Gu J; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Mu T; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Fan J; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Yang X; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Li S; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Yang T; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Sun H; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China.
  • You Q; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: youqd@163.com.
  • Zhang X; Jiangsu Key Laboratory of Drug Design and Optimization, and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zxj@cpu.edu.cn.
Bioorg Med Chem ; 24(5): 1006-13, 2016 Mar 01.
Article in En | MEDLINE | ID: mdl-26803578
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Full text: 1 Database: MEDLINE Main subject: Naphthoquinones / NAD(P)H Dehydrogenase (Quinone) / Lung Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Year: 2016 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Naphthoquinones / NAD(P)H Dehydrogenase (Quinone) / Lung Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Year: 2016 Type: Article