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In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.
Benvenuto, Monica; Masuelli, Laura; De Smaele, Enrico; Fantini, Massimo; Mattera, Rosanna; Cucchi, Danilo; Bonanno, Elena; Di Stefano, Enrica; Frajese, Giovanni Vanni; Orlandi, Augusto; Screpanti, Isabella; Gulino, Alberto; Modesti, Andrea; Bei, Roberto.
Affiliation
  • Benvenuto M; Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Masuelli L; Department of Experimental Medicine, University of Rome "Sapienza", Rome, Italy.
  • De Smaele E; Department of Experimental Medicine, University of Rome "Sapienza", Rome, Italy.
  • Fantini M; Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Mattera R; Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Cucchi D; Department of Molecular Medicine, University of Rome "Sapienza", Rome, Italy.
  • Bonanno E; Department of Molecular Medicine, University of Rome "Sapienza", Rome, Italy.
  • Di Stefano E; Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
  • Frajese GV; Department of Experimental Medicine, University of Rome "Sapienza", Rome, Italy.
  • Orlandi A; Department of Physical Education, Human Sciences and Health, University of Rome "Foro Italico", Rome, Italy.
  • Screpanti I; Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
  • Gulino A; Department of Molecular Medicine, University of Rome "Sapienza", Rome, Italy.
  • Modesti A; Department of Molecular Medicine, University of Rome "Sapienza", Rome, Italy.
  • Bei R; Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
Oncotarget ; 7(8): 9250-70, 2016 Feb 23.
Article in En | MEDLINE | ID: mdl-26843616
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Full text: 1 Database: MEDLINE Main subject: Pyridines / Pyrimidines / Breast Neoplasms / Gene Expression Regulation, Neoplastic / Carcinoma, Ductal / Zinc Finger Protein GLI1 / Smoothened Receptor / Anilides / Mammary Neoplasms, Experimental Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2016 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Pyridines / Pyrimidines / Breast Neoplasms / Gene Expression Regulation, Neoplastic / Carcinoma, Ductal / Zinc Finger Protein GLI1 / Smoothened Receptor / Anilides / Mammary Neoplasms, Experimental Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2016 Type: Article