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Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons.
Isingrini, Elsa; Perret, Léa; Rainer, Quentin; Amilhon, Bénédicte; Guma, Elisa; Tanti, Arnaud; Martin, Garance; Robinson, Jennifer; Moquin, Luc; Marti, Fabio; Mechawar, Naguib; Williams, Sylvain; Gratton, Alain; Giros, Bruno.
Affiliation
  • Isingrini E; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
  • Perret L; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
  • Rainer Q; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
  • Amilhon B; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
  • Guma E; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
  • Tanti A; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
  • Martin G; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
  • Robinson J; Sorbonne Universités, Neuroscience Paris Seine, CNRS UMR 8246, INSERM U 1130, Université Pierre et Marie Curie, Paris, France.
  • Moquin L; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
  • Marti F; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
  • Mechawar N; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
  • Williams S; Sorbonne Universités, Neuroscience Paris Seine, CNRS UMR 8246, INSERM U 1130, Université Pierre et Marie Curie, Paris, France.
  • Gratton A; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
  • Giros B; Department of Psychiatry, Douglas Mental Health Research Center, McGill University, Montreal, Quebec, Canada.
Nat Neurosci ; 19(4): 560-3, 2016 Apr.
Article in En | MEDLINE | ID: mdl-26878672
ABSTRACT
Dopamine (DA) neurons in the ventral tegmental area (VTA) help mediate stress susceptibility and resilience. However, upstream mechanisms controlling these neurons remain unknown. Noradrenergic (NE) neurons in the locus coeruleus, implicated in the pathophysiology of depression, have direct connections within the VTA. Here we demonstrate that NE neurons regulate vulnerability to social defeat through inhibitory control of VTA DA neurons.
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Full text: 1 Database: MEDLINE Main subject: Stress, Psychological / Resilience, Psychological / Dopaminergic Neurons / Adrenergic Neurons / Neural Inhibition Limits: Animals Language: En Year: 2016 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Stress, Psychological / Resilience, Psychological / Dopaminergic Neurons / Adrenergic Neurons / Neural Inhibition Limits: Animals Language: En Year: 2016 Type: Article