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Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels.
Jones, Hannah M; Butt, Richard P; Webster, Rob W; Gurrell, Ian; Dzygiel, Pawel; Flanagan, Neil; Fraier, Daniela; Hay, Tanya; Iavarone, Laura Else; Luckwell, Jacquelynn; Pearce, Hannah; Phipps, Alex; Segelbacher, Jill; Speed, Bill; Beaumont, Kevin.
Affiliation
  • Jones HM; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Butt RP; Neuroscience and Pain Research Unit, Pfizer Worldwide R&D, Granta Park, Cambridge, CB21 6GS, UK. richard.butt@pfizer.com.
  • Webster RW; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Gurrell I; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Dzygiel P; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Flanagan N; Department of Pharmaceutical Sciences, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Fraier D; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Hay T; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Iavarone LE; Clinical Pharmacology, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Luckwell J; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Pearce H; Department of Pharmaceutical Sciences, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Phipps A; Clinical Pharmacology, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Segelbacher J; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Speed B; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide R&D, Sandwich, Kent, UK.
  • Beaumont K; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide R&D, Sandwich, Kent, UK.
Clin Pharmacokinet ; 55(7): 875-887, 2016 07.
Article in En | MEDLINE | ID: mdl-26895021
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Full text: 1 Database: MEDLINE Main subject: Phenyl Ethers / Sulfonamides / Voltage-Gated Sodium Channel Blockers Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Humans / Male / Middle aged Language: En Year: 2016 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Phenyl Ethers / Sulfonamides / Voltage-Gated Sodium Channel Blockers Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Humans / Male / Middle aged Language: En Year: 2016 Type: Article