Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase.

Irani, Seema; Yogesha, S D; Mayfield, Joshua; Zhang, Mengmeng; Zhang, Yong; Matthews, Wendy L; Nie, Grace; Prescott, Nicholas A; Zhang, Yan Jessie

Irani, Seema; Yogesha, S D; Mayfield, Joshua; Zhang, Mengmeng; Zhang, Yong; Matthews, Wendy L; Nie, Grace; Prescott, Nicholas A; Zhang, Yan Jessie.

Affiliation

Irani S; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Yogesha SD; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Mayfield J; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Zhang M; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Zhang Y; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Matthews WL; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Nie G; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Prescott NA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Zhang YJ; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.

Sci Signal ; 9(417): ra24, 2016 Mar 01.

Article in En | MEDLINE | ID: mdl-26933063

Subject(s)

Catalytic Domain; Phosphoprotein Phosphatases/chemistry; Protein Domains; Protein Structure, Secondary; Saccharomyces cerevisiae Proteins/chemistry; Transcription Factors/chemistry; Amino Acid Sequence; Binding Sites/genetics; Biocatalysis/drug effects; Carrier Proteins/chemistry; Carrier Proteins/genetics; Carrier Proteins/metabolism; Crystallography, X-Ray; Enzyme Inhibitors/pharmacology; Humans; Hymecromone/analogs & derivatives; Hymecromone/metabolism; Kinetics; Marine Toxins; Metals/chemistry; Metals/metabolism; Models, Molecular; Mutation; Oxazoles/pharmacology; Phosphoprotein Phosphatases/genetics; Phosphoprotein Phosphatases/metabolism; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Sequence Homology, Amino Acid; Substrate Specificity; Sulfates/chemistry; Sulfates/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism

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Full text: 1 Database: MEDLINE Main subject: Transcription Factors / Protein Structure, Secondary / Phosphoprotein Phosphatases / Catalytic Domain / Saccharomyces cerevisiae Proteins / Protein Domains Type of study: Prognostic_studies Limits: Humans Language: En Year: 2016 Type: Article

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