Cyclopropenes in Metallacycle-Mediated Cross-Coupling with Alkynes: Convergent Synthesis of Highly Substituted Vinylcyclopropanes.
Org Lett
; 18(6): 1250-3, 2016 Mar 18.
Article
in En
| MEDLINE
| ID: mdl-26987882
ABSTRACT
Stereodivergent metallacycle-mediated cross-coupling reactions are described for the synthesis of densely functionalized vinylcyclopropanes from the union of alkynes with cyclopropenes. Strategies explored include hydroxyl-directed and nondirected processes, with the latter of these delivering vinylcyclopropanes with exquisite levels of regio- and stereoselectivity. Challenges inherent to these coupling reactions include diastereoselectivity (with respect to the cyclopropene) and regioselectivity (with respect to both coupling partners).
Full text:
1
Database:
MEDLINE
Main subject:
Vinyl Compounds
/
Cyclopropanes
/
Alkynes
Language:
En
Year:
2016
Type:
Article