New Cerebroside and Nucleoside Derivatives from a Red Sea Strain of the Marine Cyanobacterium Moorea producens.
Molecules
; 21(3): 324, 2016 Mar 09.
Article
in En
| MEDLINE
| ID: mdl-27005610
ABSTRACT
In the course of our ongoing efforts to identify marine-derived bioactive compounds, the marine cyanobacterium Moorea producens was investigated. The organic extract of the Red Sea cyanobacterium afforded one new cerebroside, mooreaside A (1), two new nucleoside derivatives, 3-acetyl-2'-deoxyuridine (2) and 3-phenylethyl-2'-deoxyuridine (3), along with the previously reported compounds thymidine (4) and 2,3-dihydroxypropyl heptacosanoate (5). The structures of the compounds were determined by different spectroscopic studies (UV, IR, 1D, 2D NMR, and HRESIMS), as well as comparison with the literature data. Compounds 1-5 showed variable cytotoxic activity against three cancer cell lines.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Cerebrosides
/
Cyanobacteria
/
Neoplasms
/
Nucleosides
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Year:
2016
Type:
Article