Callyazepin and (3R)-Methylazacyclodecane, Nitrogenous Macrocycles from a Callyspongia sp. Sponge.
J Nat Prod
; 79(4): 1179-83, 2016 Apr 22.
Article
in En
| MEDLINE
| ID: mdl-27015002
ABSTRACT
Callyazepin (1) and (3R)-methylazacyclodecane (2), nitrogenous macrocycles, were isolated from a tropical Callyspongia sp. sponge. The combined spectroscopic analyses revealed that the structure of 1 is a bicyclic azepane ammonium salt of a novel structural class derived from mixed biogenetic origins. The configuration of the whole molecule and the conformation of the formamide group were assigned by proton-proton coupling constants, a NOESY analysis, and the application of the phenylglycine methyl ester method. The structure of 2 was identified using combined spectroscopic analyses and ECD measurements. These compounds exhibited moderate cytotoxic activities against the K562 and A549 cell lines.
Full text:
1
Database:
MEDLINE
Main subject:
Callyspongia
/
Macrocyclic Compounds
/
Antineoplastic Agents
/
Nitrogen
Limits:
Animals
/
Humans
Language:
En
Year:
2016
Type:
Article