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Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.
Duvall, Jeremy R; VerPlank, Lynn; Ludeke, Barbara; McLeod, Sarah M; Lee, Maurice D; Vishwanathan, Karthick; Mulrooney, Carol A; Le Quement, Sebastian; Yu, Qin; Palmer, Michelle A; Fleming, Paul; Fearns, Rachel; Foley, Michael A; Scherer, Christina A.
Affiliation
  • Duvall JR; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA 02142, United States.
  • VerPlank L; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA 02142, United States.
  • Ludeke B; Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, United States.
  • McLeod SM; AstraZeneca R&D Boston, Infection Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Lee MD; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA 02142, United States.
  • Vishwanathan K; AstraZeneca R&D Boston, Early Clinical Development, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Mulrooney CA; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA 02142, United States.
  • Le Quement S; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA 02142, United States.
  • Yu Q; AstraZeneca R&D Boston, Infection Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Palmer MA; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA 02142, United States.
  • Fleming P; AstraZeneca R&D Boston, Infection Innovative Medicines Unit, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Fearns R; Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, United States.
  • Foley MA; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA 02142, United States.
  • Scherer CA; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA 02142, United States. Electronic address: cscherer@alum.mit.edu.
Antiviral Res ; 131: 19-25, 2016 07.
Article in En | MEDLINE | ID: mdl-27059228
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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Replicon / Microbial Sensitivity Tests / Respiratory Syncytial Virus, Human / Drug Discovery / High-Throughput Screening Assays Limits: Humans Language: En Year: 2016 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Replicon / Microbial Sensitivity Tests / Respiratory Syncytial Virus, Human / Drug Discovery / High-Throughput Screening Assays Limits: Humans Language: En Year: 2016 Type: Article