Development of cell therapy medicinal products by academic institutes.
Drug Discov Today
; 21(8): 1206-12, 2016 08.
Article
in En
| MEDLINE
| ID: mdl-27117349
ABSTRACT
In the rapidly evolving fields of cellular immunotherapy, gene therapy and regenerative medicine, a wide range of promising cell therapy medicinal products are in clinical development. Most products originate from academic research and are explored in early exploratory clinical trials. However, the success rate toward approval for regular patient care is disappointingly low. In this paper, we define strengths and hurdles applying to the development of cell therapy medicinal products in academic institutes, and analyze why only a few promising cell therapies have reached late-stage clinical development. Subsequently, we provide recommendations to stakeholders involved in development of cell therapies to exploit their potential clinical benefit.
Full text:
1
Database:
MEDLINE
Main subject:
Academies and Institutes
/
Cell- and Tissue-Based Therapy
Type of study:
Guideline
Limits:
Humans
Language:
En
Year:
2016
Type:
Article