Co-administration of &#945;-GalCer analog and TLR4 agonist induces robust CD8(+) T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells.

Coelho-Dos-Reis, Jordana G; Huang, Jing; Tsao, Tiffany; Pereira, Felipe V; Funakoshi, Ryota; Nakajima, Hiroko; Sugiyama, Haruo; Tsuji, Moriya

Co-administration of α-GalCer analog and TLR4 agonist induces robust CD8(+) T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells.

Coelho-Dos-Reis, Jordana G; Huang, Jing; Tsao, Tiffany; Pereira, Felipe V; Funakoshi, Ryota; Nakajima, Hiroko; Sugiyama, Haruo; Tsuji, Moriya.

Affiliation

Coelho-Dos-Reis JG; Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA; Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz - FIOCRUZ, Minas Gerais 30192, Brazil. Electronic address: jordana.reis@cpqrr.fiocruz.br.
Huang J; Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA.
Tsao T; Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA.
Pereira FV; Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA; Federal University of Sao Paulo, Sao Paulo 04021, Brazil.
Funakoshi R; Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA.
Nakajima H; Department of Cancer Immunology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Sugiyama H; Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Tsuji M; Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA. Electronic address: mtsuji@adarc.org.

Clin Immunol ; 168: 6-15, 2016 07.

Article in En | MEDLINE | ID: mdl-27132023

Subject(s)

CD8-Positive T-Lymphocytes/drug effects; Galactosylceramides/pharmacology; Killer Cells, Natural/drug effects; Lipid A/analogs & derivatives; Toll-Like Receptor 4/agonists; Amino Acid Sequence; Animals; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/metabolism; Cell Line, Tumor; Drug Synergism; Epitopes, T-Lymphocyte/immunology; Galactosylceramides/administration & dosage; HLA-A2 Antigen/genetics; HLA-A2 Antigen/immunology; Humans; Immunization/methods; Immunologic Memory/immunology; Interferon-gamma/immunology; Interferon-gamma/metabolism; Killer Cells, Natural/immunology; Killer Cells, Natural/metabolism; Lipid A/administration & dosage; Lipid A/pharmacology; Malaria/immunology; Malaria/parasitology; Malaria/prevention & control; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Models, Immunological; Peptides/immunology; Plasmodium yoelii/immunology; Plasmodium yoelii/physiology; Protective Agents/administration & dosage; Protective Agents/pharmacology; Protozoan Proteins/chemistry; Protozoan Proteins/immunology; Toll-Like Receptor 4/metabolism; WT1 Proteins/genetics; WT1 Proteins/immunology

Key words

Adjuvant; CD1d; Cancer vaccine; Circumsporozoite protein; Glycolipid; Malaria vaccine; Memory-like effector NKT cells; NKT cells; TLR4; WT-1

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Full text: 1 Database: MEDLINE Main subject: Killer Cells, Natural / CD8-Positive T-Lymphocytes / Toll-Like Receptor 4 / Galactosylceramides / Lipid A Language: En Year: 2016 Type: Article

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