Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study).
Nefrologia
; 36(3): 255-67, 2016.
Article
in En, Es
| MEDLINE
| ID: mdl-27133898
ABSTRACT
BACKGROUND AND OBJECTIVES:
The relationship between mineral metabolism disorders, bone fractures and vascular calcifications in kidney transplant recipients has not been established.METHOD:
We performed a cross-sectional study in 727 stable recipients from 28 Spanish transplant clinics. Mineral metabolism parameters, the semi-quantification of vertebral fractures and abdominal aortic calcifications were determined centrally.RESULTS:
Vitamin D deficiency (25OHD3<15ng/ml) was more common in female recipients at CKD-T stages I-III (29.6% vs 44.4%; p=0.003). The inverse and significant correlation between 25OHD3 and PTH was gender-specific and women exhibited a steeper slope than men (p=0.01). Vertebral fractures (VFx) with deformity grade ≥2 were observed in 15% of recipients. Factors related to VFx differed by gender; in males, age (OR 1.04; 95% CI 1.01-1.06) and CsA treatment (OR 3.2; 95% CI 1.6-6.3); in females, age (OR 1.07; 95% CI 1.03-1.12) and PTH levels (OR per 100pg/ml increase 1.27; 95% CI 1.043-1.542). Abdominal aortic calcifications were common (67.2%) and related to classical risk factors but not to mineral metabolism parameters.CONCLUSIONS:
Vitamin D deficiency is more common among female kidney transplant recipients at earlier CKD-T stages, and it contributes to secondary hyperparathyroidism. Prevalent vertebral fractures are only related to high serum PTH levels in female recipients.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Aortic Diseases
/
Postoperative Complications
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Calcinosis
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Sex Factors
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Spinal Fractures
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Kidney Transplantation
/
Minerals
Type of study:
Clinical_trials
/
Etiology_studies
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Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Aged
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Female
/
Humans
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Male
/
Middle aged
Language:
En
/
Es
Year:
2016
Type:
Article