Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer.

Kan, Jung-Yu; Yen, Meng-Chi; Wang, Jaw-Yuan; Wu, Deng-Chyang; Chiu, Yen-Jung; Ho, Ya-Wen; Kuo, Po-Lin

Kan, Jung-Yu; Yen, Meng-Chi; Wang, Jaw-Yuan; Wu, Deng-Chyang; Chiu, Yen-Jung; Ho, Ya-Wen; Kuo, Po-Lin.

Affiliation

Kan JY; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yen MC; Division of Gastrointestinal and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Wang JY; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wu DC; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chiu YJ; Division of Gastrointestinal and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Ho YW; Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kuo PL; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Oncotarget ; 7(21): 31336-49, 2016 May 24.

Article in En | MEDLINE | ID: mdl-27150059

Subject(s)

AMP-Activated Protein Kinases/genetics; Calcium-Binding Proteins/genetics; Cell Movement/genetics; Colonic Neoplasms/genetics; DNA-Binding Proteins/genetics; Epithelial-Mesenchymal Transition/genetics; Mechanistic Target of Rapamycin Complex 1/genetics; Nerve Tissue Proteins/genetics; Protein Serine-Threonine Kinases/genetics; Zinc Finger E-box-Binding Homeobox 1/genetics; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases/metabolism; Adult; Animals; Calcium-Binding Proteins/metabolism; Cell Line, Tumor; Colonic Neoplasms/metabolism; Colonic Neoplasms/pathology; DNA-Binding Proteins/metabolism; Gene Expression Profiling/methods; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Male; Mechanistic Target of Rapamycin Complex 1/metabolism; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasms, Experimental/genetics; Neoplasms, Experimental/metabolism; Neoplasms, Experimental/pathology; Nerve Tissue Proteins/metabolism; Nucleobindins; Protein Serine-Threonine Kinases/metabolism; RNA Interference; Signal Transduction/genetics; Zinc Finger E-box-Binding Homeobox 1/metabolism

Key words

EMT; Nucleobindin-2 (NUCB-2); colon cancer; metastasis; nesfatin-1

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Full text: 1 Database: MEDLINE Main subject: Calcium-Binding Proteins / Cell Movement / Protein Serine-Threonine Kinases / Colonic Neoplasms / DNA-Binding Proteins / AMP-Activated Protein Kinases / Epithelial-Mesenchymal Transition / Zinc Finger E-box-Binding Homeobox 1 / Mechanistic Target of Rapamycin Complex 1 / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Adult / Animals / Humans / Male Language: En Year: 2016 Type: Article

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