Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease.

Heaven, Michael R; Flint, Daniel; Randall, Shan M; Sosunov, Alexander A; Wilson, Landon; Barnes, Stephen; Goldman, James E; Muddiman, David C; Brenner, Michael

Heaven, Michael R; Flint, Daniel; Randall, Shan M; Sosunov, Alexander A; Wilson, Landon; Barnes, Stephen; Goldman, James E; Muddiman, David C; Brenner, Michael.

Affiliation

Randall SM; Keck Fourier Transform Mass Spectrometry Laboratory, Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United States.
Muddiman DC; Keck Fourier Transform Mass Spectrometry Laboratory, Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United States.

J Proteome Res ; 15(7): 2265-82, 2016 07 01.

Article in En | MEDLINE | ID: mdl-27193225

Subject(s)

Alexander Disease; Protein Aggregates; Proteome/analysis; Animals; Astrocytes; Cyclin D2/analysis; DEAD-box RNA Helicases/analysis; GTP-Binding Proteins/analysis; Humans; Immunohistochemistry; Mice; Neoplasm Proteins/analysis; Neuropeptides/analysis; Protein Aggregation, Pathological; RNA Helicases/analysis; Receptors for Activated C Kinase; Receptors, Cell Surface/analysis

Key words

Alexander disease; Rosenthal fiber; astrocyte; mass spectrometry (MS); neurodegenerative disease; protein aggregates; proteomics; stress granules

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Full text: 1 Database: MEDLINE Main subject: Proteome / Alexander Disease / Protein Aggregates Limits: Animals / Humans Language: En Year: 2016 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Proteome / Alexander Disease / Protein Aggregates Limits: Animals / Humans Language: En Year: 2016 Type: Article