A critical role of T follicular helper cells in human mucosal anti-influenza response that can be enhanced by immunological adjuvant CpG-DNA.

Aljurayyan, A N; Sharma, R; Upile, N; Beer, H; Vaughan, C; Xie, C; Achar, P; Ahmed, M S; McNamara, P S; Gordon, S B; Zhang, Q

Aljurayyan, A N; Sharma, R; Upile, N; Beer, H; Vaughan, C; Xie, C; Achar, P; Ahmed, M S; McNamara, P S; Gordon, S B; Zhang, Q.

Affiliation

Aljurayyan AN; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, United Kingdom; Immunology & HLA section, Pathology & Clinical Laboratory Medicine, King Fahad Medical City, Saudi Arabia.
Sharma R; ENT Department, Alder Hey Children's Hospital, United Kingdom.
Upile N; ENT Department, Alder Hey Children's Hospital, United Kingdom.
Beer H; ENT Department, Alder Hey Children's Hospital, United Kingdom.
Vaughan C; ENT Department, Alder Hey Children's Hospital, United Kingdom.
Xie C; ENT Department, Alder Hey Children's Hospital, United Kingdom.
Achar P; ENT Department, Royal Liverpool and Broadgreen University Hospitals, United Kingdom.
Ahmed MS; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, United Kingdom.
McNamara PS; Institute of Child Health, University of Liverpool, United Kingdom.
Gordon SB; Liverpool School of Tropical Medicine, United Kingdom.
Zhang Q; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, United Kingdom. Electronic address: qibo.zhang@liv.ac.uk.

Antiviral Res ; 132: 122-30, 2016 08.

Article in En | MEDLINE | ID: mdl-27247060

Subject(s)

Adjuvants, Immunologic; Influenza, Human/immunology; Influenza, Human/virology; Mucous Membrane/immunology; Mucous Membrane/virology; Oligodeoxyribonucleotides/immunology; T-Lymphocytes, Helper-Inducer/immunology; Adolescent; Adult; Antibodies, Viral/immunology; Antibody Formation/immunology; Antibody Specificity/immunology; Antigens/immunology; Child; Child, Preschool; Cytokines/biosynthesis; Hemagglutinin Glycoproteins, Influenza Virus/immunology; Humans; Immunomodulation; Immunophenotyping; Infant; Influenza Vaccines/immunology; Influenza, Human/metabolism; Lymphocyte Count; Mucous Membrane/metabolism; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism; T-Lymphocytes, Helper-Inducer/metabolism; Young Adult

Key words

Anti-hemagglutinin (HA) antibody response; Children and adults; CpG-DNA; Influenza vaccine; Influenza virus; Nasopharynx-associated lymphoid tissues (NALT); T follicular helper cell (T(FH))

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Full text: 1 Database: MEDLINE Main subject: Oligodeoxyribonucleotides / Adjuvants, Immunologic / T-Lymphocytes, Helper-Inducer / Influenza, Human / Mucous Membrane Limits: Adolescent / Adult / Child / Child, preschool / Humans / Infant Language: En Year: 2016 Type: Article

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