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A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells.
Ma, Qing; Garber, Haven R; Lu, Sijie; He, Hong; Tallis, Eran; Ding, Xiaoling; Sergeeva, Anna; Wood, Michael S; Dotti, Gianpietro; Salvado, Barbara; Ruisaard, Kathryn; Clise-Dwyer, Karen; John, Lisa St; Rezvani, Katayoun; Alatrash, Gheath; Shpall, Elizabeth J; Molldrem, Jeffrey J.
Affiliation
  • Ma Q; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • Garber HR; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • Lu S; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • He H; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • Tallis E; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • Ding X; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • Sergeeva A; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • Wood MS; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.
  • Dotti G; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.
  • Salvado B; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.
  • Ruisaard K; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • Clise-Dwyer K; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • John LS; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • Rezvani K; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • Alatrash G; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • Shpall EJ; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA.
  • Molldrem JJ; Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, Texas, USA. Electronic address: jmolldre@mdanderson.org.
Cytotherapy ; 18(8): 985-994, 2016 08.
Article in En | MEDLINE | ID: mdl-27265873
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Full text: 1 Database: MEDLINE Main subject: Leukocytes, Mononuclear / Receptors, Antigen, T-Cell / T-Lymphocytes / Leukemia, Myeloid, Acute / HLA-A2 Antigen / Myeloblastin / Fetal Blood Limits: Adult / Humans Language: En Year: 2016 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Leukocytes, Mononuclear / Receptors, Antigen, T-Cell / T-Lymphocytes / Leukemia, Myeloid, Acute / HLA-A2 Antigen / Myeloblastin / Fetal Blood Limits: Adult / Humans Language: En Year: 2016 Type: Article