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Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin.
Elf, S; Lin, R; Xia, S; Pan, Y; Shan, C; Wu, S; Lonial, S; Gaddh, M; Arellano, M L; Khoury, H J; Khuri, F R; Lee, B H; Boggon, T J; Fan, J; Chen, J.
Affiliation
  • Elf S; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
  • Lin R; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
  • Xia S; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
  • Pan Y; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
  • Shan C; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
  • Wu S; Department of Chemistry, Emory University School of Medicine, Atlanta, GA, USA.
  • Lonial S; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
  • Gaddh M; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
  • Arellano ML; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
  • Khoury HJ; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
  • Khuri FR; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
  • Lee BH; Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Boggon TJ; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
  • Fan J; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
  • Chen J; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA, USA.
Oncogene ; 36(2): 254-262, 2017 01 12.
Article in En | MEDLINE | ID: mdl-27270429
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Full text: 1 Database: MEDLINE Main subject: Pentose Phosphate Pathway / Phosphogluconate Dehydrogenase / Leukemia / Antineoplastic Combined Chemotherapy Protocols / Emodin / Antimalarials Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2017 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Pentose Phosphate Pathway / Phosphogluconate Dehydrogenase / Leukemia / Antineoplastic Combined Chemotherapy Protocols / Emodin / Antimalarials Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2017 Type: Article