Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor.

Iwasaki, Shintaro; Floor, Stephen N; Ingolia, Nicholas T

Iwasaki, Shintaro; Floor, Stephen N; Ingolia, Nicholas T.

Affiliation

Iwasaki S; Department of Molecular and Cell Biology, Center for RNA Systems Biology, University of California, Berkeley, California 94720, USA.
Floor SN; Department of Molecular and Cell Biology, Center for RNA Systems Biology, University of California, Berkeley, California 94720, USA.
Ingolia NT; Department of Molecular and Cell Biology, Center for RNA Systems Biology, University of California, Berkeley, California 94720, USA.

Nature ; 534(7608): 558-61, 2016 06 23.

Article in En | MEDLINE | ID: mdl-27309803

Subject(s)

Benzofurans/pharmacology; Eukaryotic Initiation Factor-4A/metabolism; Protein Biosynthesis/drug effects; RNA, Messenger/genetics; RNA, Messenger/metabolism; Repressor Proteins/metabolism; 5' Untranslated Regions/genetics; Adenosine Triphosphate/metabolism; DEAD-box RNA Helicases/chemistry; DEAD-box RNA Helicases/metabolism; Eukaryotic Initiation Factor-4A/chemistry; HEK293 Cells; Humans; Hydrolysis; Nucleic Acid Conformation; Nucleotide Motifs; Open Reading Frames/genetics; Peptide Chain Initiation, Translational/drug effects; Protein Binding/drug effects; Protein Stability/drug effects; RNA, Messenger/chemistry; RNA-Binding Proteins/chemistry; RNA-Binding Proteins/metabolism; Repressor Proteins/chemistry; Substrate Specificity/drug effects; Thermodynamics

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Full text: 1 Database: MEDLINE Main subject: Repressor Proteins / Protein Biosynthesis / Benzofurans / RNA, Messenger / Eukaryotic Initiation Factor-4A Limits: Humans Language: En Year: 2016 Type: Article

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