Phase IA Clinical Trial Evaluating the Tolerability, Pharmacokinetics, and Analgesic Efficacy of an Intrathecally Administered Neurotensin A Analogue in Central Neuropathic Pain Following Spinal Cord Injury.

Sang, Christine N; Barnabe, Kate J; Kern, Steven E

Sang, Christine N; Barnabe, Kate J; Kern, Steven E.

Affiliation

Sang CN; Translational Pain Research, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Barnabe KJ; Translational Pain Research, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kern SE; Quantitative Science, Bill & Melinda Gates Foundation, Seattle, WA, USA.

Clin Pharmacol Drug Dev ; 5(4): 250-8, 2016 Jul.

Article in En | MEDLINE | ID: mdl-27310326

Subject(s)

Analgesics/administration & dosage; Glycoproteins/administration & dosage; Neuralgia/drug therapy; Neuropeptides/administration & dosage; Spinal Cord Injuries/drug therapy; Analgesics/adverse effects; Analgesics/pharmacokinetics; Dose-Response Relationship, Drug; Glycoproteins/adverse effects; Glycoproteins/pharmacokinetics; Humans; Injections, Spinal; Maximum Tolerated Dose; Models, Biological; Neuralgia/etiology; Neuropeptides/adverse effects; Neuropeptides/pharmacokinetics; Neurotensin/analogs & derivatives; Treatment Outcome

Key words

central neuropathic pain; conotoxin; pharmacodynamics; pharmacokinetics; spinal cord injury

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Full text: 1 Database: MEDLINE Main subject: Spinal Cord Injuries / Neuropeptides / Glycoproteins / Analgesics / Neuralgia Type of study: Etiology_studies Limits: Humans Language: En Year: 2016 Type: Article

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