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Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo.
Evans, James C; Malhotra, Meenakshi; Guo, Jianfeng; O'Shea, Joseph P; Hanrahan, Karen; O'Neill, Amanda; Landry, William D; Griffin, Brendan T; Darcy, Raphael; Watson, R William; O'Driscoll, Caitriona M.
Affiliation
  • Evans JC; Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland.
  • Malhotra M; Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland.
  • Guo J; Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland.
  • O'Shea JP; Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland.
  • Hanrahan K; UCD Conway Institute of Biomolecular and Biomedical Research, UCD School of Medicine, University College Dublin, Dublin, Ireland.
  • O'Neill A; UCD Conway Institute of Biomolecular and Biomedical Research, UCD School of Medicine, University College Dublin, Dublin, Ireland.
  • Landry WD; Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland.
  • Griffin BT; Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland.
  • Darcy R; Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland.
  • Watson RW; UCD Conway Institute of Biomolecular and Biomedical Research, UCD School of Medicine, University College Dublin, Dublin, Ireland.
  • O'Driscoll CM; Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland. Electronic address: caitriona.odriscoll@ucc.ie.
Nanomedicine ; 12(8): 2341-2351, 2016 11.
Article in En | MEDLINE | ID: mdl-27389146
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Full text: 1 Database: MEDLINE Main subject: Prostatic Neoplasms / RNA, Small Interfering / Nanoparticles Limits: Humans / Male Language: En Year: 2016 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Prostatic Neoplasms / RNA, Small Interfering / Nanoparticles Limits: Humans / Male Language: En Year: 2016 Type: Article