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Targeted disruption of BMP signaling through type IA receptor (BMPR1A) in osteocyte suppresses SOST and RANKL, leading to dramatic increase in bone mass, bone mineral density and mechanical strength.
Kamiya, Nobuhiro; Shuxian, Lin; Yamaguchi, Ryosuke; Phipps, Matthew; Aruwajoye, Olumide; Adapala, Naga Suresh; Yuan, Hui; Kim, Harry K W; Feng, Jian Q.
Affiliation
  • Kamiya N; Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA; Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-8883, USA; Sports Medicine, Tenri University, Tenri, Nara 632-0071, Japan. Electronic address: nkamiya1@sta.tenri-u.ac.jp.
  • Shuxian L; Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA; Department of Prosthodontics, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
  • Yamaguchi R; Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA.
  • Phipps M; Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA.
  • Aruwajoye O; Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA.
  • Adapala NS; Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA; Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-8883, USA.
  • Yuan H; Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA.
  • Kim HK; Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA; Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-8883, USA.
  • Feng JQ; Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA. Electronic address: Jfeng@bcd.tamhsc.edu.
Bone ; 91: 53-63, 2016 10.
Article in En | MEDLINE | ID: mdl-27402532
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Full text: 1 Database: MEDLINE Main subject: Bone and Bones / Glycoproteins / Bone Density / Bone Morphogenetic Proteins / Bone Morphogenetic Protein Receptors, Type I / RANK Ligand Type of study: Prognostic_studies Limits: Animals Language: En Year: 2016 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Bone and Bones / Glycoproteins / Bone Density / Bone Morphogenetic Proteins / Bone Morphogenetic Protein Receptors, Type I / RANK Ligand Type of study: Prognostic_studies Limits: Animals Language: En Year: 2016 Type: Article