Tocilizumab and mesenteric arterial thrombosis: drug-drug interaction with anticoagulants metabolized by CYP 450 and/or by P-glycoprotein.

Clarivet, B; Robin, P; Pers, Y M; Ferreira, R; Lebrun, J; Jorgensen, C; Hillaire-Buys, D; Brés, V; Faillie, J L

Clarivet, B; Robin, P; Pers, Y M; Ferreira, R; Lebrun, J; Jorgensen, C; Hillaire-Buys, D; Brés, V; Faillie, J L.

Affiliation

Clarivet B; Pharmacovigilance Regional Centre, Department of Medical Pharmacology and Toxicology, CHU Montpellier University Hospital, Montpellier, France. b-clarivet@chu-montpellier.fr.
Robin P; Pharmacovigilance Regional Centre, Department of Medical Pharmacology and Toxicology, CHU Montpellier University Hospital, Montpellier, France.
Pers YM; Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Montpellier University Hospital, Montpellier, France.
Ferreira R; Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Montpellier University Hospital, Montpellier, France.
Lebrun J; Pharmacovigilance Regional Centre, Department of Medical Pharmacology and Toxicology, CHU Montpellier University Hospital, Montpellier, France.
Jorgensen C; Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Montpellier University Hospital, Montpellier, France.
Hillaire-Buys D; Pharmacovigilance Regional Centre, Department of Medical Pharmacology and Toxicology, CHU Montpellier University Hospital, Montpellier, France.
Brés V; Pharmacovigilance Regional Centre, Department of Medical Pharmacology and Toxicology, CHU Montpellier University Hospital, Montpellier, France.
Faillie JL; Pharmacovigilance Regional Centre, Department of Medical Pharmacology and Toxicology, CHU Montpellier University Hospital, Montpellier, France.

Eur J Clin Pharmacol ; 72(11): 1413-1414, 2016 Nov.

Article in En | MEDLINE | ID: mdl-27457374

Subject(s)

Antibodies, Monoclonal, Humanized/therapeutic use; Anticoagulants/therapeutic use; Antirheumatic Agents/therapeutic use; Dabigatran/therapeutic use; Mesenteric Ischemia/etiology; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Antibodies, Monoclonal, Humanized/pharmacokinetics; Anticoagulants/pharmacokinetics; Antirheumatic Agents/pharmacokinetics; Arthritis, Rheumatoid/drug therapy; Atrial Fibrillation/drug therapy; Cytochrome P-450 Enzyme System/metabolism; Dabigatran/pharmacokinetics; Drug Interactions; Female; Humans; Middle Aged; Receptors, Interleukin-6/antagonists & inhibitors; Receptors, Interleukin-6/immunology

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Database: MEDLINE Main subject: Antirheumatic Agents / Antibodies, Monoclonal, Humanized / Mesenteric Ischemia / Dabigatran / Anticoagulants Limits: Female / Humans / Middle aged Language: En Year: 2016 Type: Article

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