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Semi-automatic Volumetric Measurement of Treatment Response in Hepatocellular Carcinoma After Trans-arterial Chemoembolization.
Budjan, Johannes; Sauter, Elke A; Morelli, John N; Nolden, Marco; Fetzer, Andreas; Pilz, Lothar; Reichert, Miriam; Brandt, Theresa; Hansmann, Jan; Haneder, Stefan; Rathmann, Nils; Diehl, Steffen J; Meinzer, Hans-Peter; Schoenberg, Stefan O; Attenberger, Ulrike I.
Affiliation
  • Budjan J; Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany johannes.budjan@umm.de.
  • Sauter EA; Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Morelli JN; St. John's Medical Center, Tulsa, OK, U.S.A.
  • Nolden M; Division of Medical and Biological Informatics, German Cancer Research Centre, Heidelberg, Germany.
  • Fetzer A; Division of Medical and Biological Informatics, German Cancer Research Centre, Heidelberg, Germany.
  • Pilz L; Department of Biostatistics, University Medical Center Mannheim, Medical Faculty Mannheim, Mannheim, Germany.
  • Reichert M; Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Brandt T; Division of Medical and Biological Informatics, German Cancer Research Centre, Heidelberg, Germany.
  • Hansmann J; Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Haneder S; University Hospital of Cologne, Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany.
  • Rathmann N; Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Diehl SJ; Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Meinzer HP; Division of Medical and Biological Informatics, German Cancer Research Centre, Heidelberg, Germany.
  • Schoenberg SO; Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Attenberger UI; Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Anticancer Res ; 36(8): 4353-8, 2016 Aug.
Article in En | MEDLINE | ID: mdl-27466556
ABSTRACT

AIM:

To perform a quantitative, volumetric analysis of therapeutic effects of trans-arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients. PATIENTS AND

METHODS:

Entire tumor volume and a subset of hypervascular tumor portions were analyzed pre- and post-TACE in magnetic resonance imaging datasets of 22 HCC patients using a semi-automated segmentation and evaluation tool from the Medical Imaging Interaction Toolkit. Results were compared to mRECIST measurements and inter-reader variability was assessed.

RESULTS:

Mean total tumor volume increased statistical significantly after TACE (84.6 ml pre- vs. 97.1 ml post-TACE, p=0.03) while hypervascular tumor volume decreased from 9.1 ml pre- to 3.7 ml post-TACE (p=0.0001). Likewise, mRECIST diameters decreased significantly after therapy (44.2 vs. 15.4 mm). In the inter-reader assessment, overlap errors were 12.3-17.7% for entire and 36.3-64.2% for the enhancing tumor volume.

CONCLUSION:

Quantification of therapeutic changes after TACE therapy is feasible using a semi-automated segmentation and evaluation tool. Following TACE, hypervascular tumor volume decreases significantly.
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Database: MEDLINE Main subject: Magnetic Resonance Imaging / Chemoembolization, Therapeutic / Carcinoma, Hepatocellular / Liver Neoplasms Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2016 Type: Article
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PubMed Links

Database: MEDLINE Main subject: Magnetic Resonance Imaging / Chemoembolization, Therapeutic / Carcinoma, Hepatocellular / Liver Neoplasms Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2016 Type: Article