Your browser doesn't support javascript.
loading
Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males.
Ji, Huihui; Wang, Yunliang; Jiang, Danjie; Liu, Guili; Xu, Xuting; Dai, Dongjun; Zhou, Xiaohui; Cui, Wei; Li, Jinfeng; Chen, Zhongming; Li, Ying; Zhou, Dongsheng; Zha, Qin; Zhuo, Renjie; Jiang, Liting; Liu, Yu; Shen, Lili; Zhang, Beibei; Xu, Lei; Hu, Haochang; Zhang, Yuzheng; Yin, Honglei; Duan, Shiwei; Wang, Qinwen.
Affiliation
  • Ji H; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Wang Y; Department of Neurology, The 148 Central Hospital of PLA, Zibo, Shandong 255000, P.R. China.
  • Jiang D; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Liu G; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Xu X; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Dai D; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Zhou X; Department of Internal Medicine for Cadres, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang 830000, P.R. China.
  • Cui W; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Li J; Department of Neurology, The 148 Central Hospital of PLA, Zibo, Shandong 255000, P.R. China.
  • Chen Z; Geriatric Department, Ningbo Kangning Hospital, Ningbo, Zhejiang 315201, P.R. China.
  • Li Y; Geriatric Department, Ningbo No. 1 Hospital, Ningbo, Zhejiang 315010, P.R. China.
  • Zhou D; Geriatric Department, Ningbo Kangning Hospital, Ningbo, Zhejiang 315201, P.R. China.
  • Zha Q; Geriatric Department, The Affiliated Hospital of School of Medicine of Ningbo University, Ningbo, Zhejiang 315200, P.R. China.
  • Zhuo R; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Jiang L; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Liu Y; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Shen L; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Zhang B; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Xu L; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Hu H; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Zhang Y; Department of Neurology, The 148 Central Hospital of PLA, Zibo, Shandong 255000, P.R. China.
  • Yin H; Department of Neurology, The 148 Central Hospital of PLA, Zibo, Shandong 255000, P.R. China.
  • Duan S; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
  • Wang Q; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Mol Med Rep ; 14(3): 2732-8, 2016 Sep.
Article in En | MEDLINE | ID: mdl-27485706
ABSTRACT
Aberrant promoter methylation of multiple genes is associated with various diseases, including Alzheimer's disease (AD). The goal of the present study was to determine whether dopamine receptor D4 (DRD4) promoter methylation is associated with AD. In the current study, the methylation levels of the DRD4 promoter were measured in 46 AD patients and 61 controls using bisulfite pyrosequencing technology. The results of the present study demonstrated that DRD4 promoter methylation was significantly higher in AD patients than in controls. A further breakdown analysis by gender revealed that there was a significant association of DRD4 promoter methylation with AD in males (23 patients and 45 controls). In conclusion, the results of the present study demonstrated that elevated DRD4 promoter methylation was associated with AD risk in males.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Promoter Regions, Genetic / DNA Methylation / Receptors, Dopamine D4 / Alzheimer Disease Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Humans / Male Language: En Year: 2016 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Promoter Regions, Genetic / DNA Methylation / Receptors, Dopamine D4 / Alzheimer Disease Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Humans / Male Language: En Year: 2016 Type: Article