PDE4 Differential Expression Is a Potential Prognostic Factor and Therapeutic Target in Patients With Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia.

Chamseddine, Ali N; Cabrero, Monica; Wei, Yue; Ganan-Gomez, Irene; Colla, Simona; Takahashi, Koichi; Yang, Hui; Bohannan, Zachary S; Garcia-Manero, Guillermo

Chamseddine, Ali N; Cabrero, Monica; Wei, Yue; Ganan-Gomez, Irene; Colla, Simona; Takahashi, Koichi; Yang, Hui; Bohannan, Zachary S; Garcia-Manero, Guillermo.

Affiliation

Chamseddine AN; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: alichamseddine@hotmail.com.
Cabrero M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Wei Y; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Ganan-Gomez I; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Colla S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Takahashi K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Yang H; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Bohannan ZS; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Garcia-Manero G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.

Clin Lymphoma Myeloma Leuk ; 16 Suppl: S67-73, 2016 08.

Article in En | MEDLINE | ID: mdl-27521329

Subject(s)

Cyclic Nucleotide Phosphodiesterases, Type 4/genetics; Gene Expression; Leukemia, Myelomonocytic, Chronic/genetics; Myelodysplastic Syndromes/genetics; Adult; Aged; Aged, 80 and over; Bone Marrow/pathology; Combined Modality Therapy; Female; Follow-Up Studies; Gene Expression Profiling; Humans; Interleukin-8/genetics; Interleukin-8/metabolism; Kaplan-Meier Estimate; Leukemia, Myelomonocytic, Chronic/diagnosis; Leukemia, Myelomonocytic, Chronic/drug therapy; Leukemia, Myelomonocytic, Chronic/mortality; Male; Middle Aged; Molecular Targeted Therapy; Myelodysplastic Syndromes/diagnosis; Myelodysplastic Syndromes/drug therapy; Myelodysplastic Syndromes/mortality; Phosphodiesterase 4 Inhibitors/therapeutic use; Prognosis; Protein Isoforms; Retreatment; Severity of Illness Index; Treatment Outcome

Key words

Chronic myelomonocytic leukemia (CMML); Inflammation; Myelodysplastic syndromes (MDS); Phosphodiesterase 4 (PDE4); Prognosis

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Full text: 1 Database: MEDLINE Main subject: Myelodysplastic Syndromes / Leukemia, Myelomonocytic, Chronic / Gene Expression / Cyclic Nucleotide Phosphodiesterases, Type 4 Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2016 Type: Article

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