Monitoring and Management of Immune-Related Adverse Events Associated With Programmed Cell Death Protein-1 Axis Inhibitors in Lung Cancer.
Oncologist
; 22(1): 70-80, 2017 01.
Article
in En
| MEDLINE
| ID: mdl-27534573
ABSTRACT
Monoclonal antibodies targeting programmed cell death protein-1 (PD-1) represent a new treatment paradigm in non-small cell lung cancer. Three phase III trials have demonstrated a survival benefit and improved tolerability of nivolumab and pembrolizumab when compared with standard second-line chemotherapy. Nevertheless, the adverse events associated with PD-1 inhibitors are unique; early recognition and treatment are essential. This review summarizes the required monitoring and appropriate management of immune-related adverse events in lung cancer patients receiving these agents. THE ONCOLOGIST 2017;2270-80 IMPLICATIONS FOR PRACTICE The potential adverse events of immune checkpoint inhibitors differ from conventional chemotherapy and can require a multidisciplinary approach. Continued education is important for all physicians to ensure optimal care for patients.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Drug-Related Side Effects and Adverse Reactions
/
B7-H1 Antigen
/
Programmed Cell Death 1 Receptor
/
Lung Neoplasms
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Year:
2017
Type:
Article