Nuclear and cytoplasmic features in the diagnosis of banal nevi, Spitz nevi, and melanoma.
J Am Acad Dermatol
; 75(5): 1032-1037.e8, 2016 Nov.
Article
in En
| MEDLINE
| ID: mdl-27542585
ABSTRACT
BACKGROUND:
Many authors have described cytologic features in a variety of melanocytic lesions but, to our knowledge, a statistical analysis of sensitivity, specificity, and overall accuracy of these features alone or in combination has not been performed.OBJECTIVE:
We sought to determine the diagnostic value of nuclear and cytoplasmic characteristics in the diagnosis of melanocytic lesions via multivariate statistical analysis.METHODS:
This is a retrospective observational study conducted on 300 melanocytic lesions. We evaluated a series of distinctive features; subsequently a multivariate model was used to determine sensitivity and specificity.RESULTS:
Major features that favor a diagnosis of melanoma include pleomorphism with enlarged nuclei, mitotic figures, notching/corrugation of the nuclear envelope, and peppered moth nucleus. Features with intermediate value include solid hyperchromasia, vesicular nucleus with single round nucleolus, and nuclear/cytoplasmic ratio greater than 41.LIMITATIONS:
Limitations of this study include its retrospective nature, and the reliance on the original diagnostic classification of each neoplasm.CONCLUSION:
Our data suggest that some nuclear alterations have greater value in the diagnosis of benign and malignant melanocytic lesions.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Cell Nucleus
/
Nevus, Epithelioid and Spindle Cell
/
Cytoplasm
/
Melanoma
/
Nevus, Pigmented
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Year:
2016
Type:
Article