Unique pharmacological property of ISRIB in inhibition of Aß-induced neuronal cell death.
J Pharmacol Sci
; 131(4): 292-5, 2016 Aug.
Article
in En
| MEDLINE
| ID: mdl-27569458
ABSTRACT
A pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated the pharmacological characteristics of the recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB potently attenuated amyloid ß-induced neuronal cell death at concentrations of 12.5-25 nM, but did not inhibit amyloid ß production in the HEK293T cell line expressing the amyloid precursor protein (APP). These results suggest that ISRIB possesses the unique pharmacological property of attenuating amyloid ß-induced neuronal cell death without affecting amyloid ß production.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Amyloid beta-Peptides
/
Cell Death
/
Cyclohexylamines
/
Acetamides
/
Neurons
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Year:
2016
Type:
Article