Endoperoxide Drug Cross-Resistance Patterns for Plasmodium falciparum Exhibiting an Artemisinin Delayed-Clearance Phenotype.

Siriwardana, A; Iyengar, K; Roepe, P D

Siriwardana, A; Iyengar, K; Roepe, P D.

Affiliation

Siriwardana A; Departments of Chemistry and of Biochemistry and Cellular and Molecular Biology, Georgetown University, Washington, DC, USA.
Iyengar K; Departments of Chemistry and of Biochemistry and Cellular and Molecular Biology, Georgetown University, Washington, DC, USA.
Roepe PD; Departments of Chemistry and of Biochemistry and Cellular and Molecular Biology, Georgetown University, Washington, DC, USA paul.roepe@georgetown.edu.

Antimicrob Agents Chemother ; 60(11): 6952-6956, 2016 11.

Article in En | MEDLINE | ID: mdl-27600038

Subject(s)

Antimalarials/pharmacology; Artemisinins/pharmacology; Drug Resistance/drug effects; Plasmodium falciparum/drug effects; Adamantane/analogs & derivatives; Adamantane/pharmacokinetics; Adamantane/pharmacology; Antimalarials/administration & dosage; Antimalarials/pharmacokinetics; Artemether; Artemisinins/administration & dosage; Artemisinins/pharmacokinetics; Dose-Response Relationship, Drug; Heterocyclic Compounds, 1-Ring/administration & dosage; Heterocyclic Compounds, 1-Ring/pharmacokinetics; Heterocyclic Compounds, 1-Ring/pharmacology; Inactivation, Metabolic; Lethal Dose 50; Microbial Sensitivity Tests; Peroxides/administration & dosage; Peroxides/pharmacokinetics; Peroxides/pharmacology; Spiro Compounds/administration & dosage; Spiro Compounds/pharmacokinetics; Spiro Compounds/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Plasmodium falciparum / Drug Resistance / Artemisinins / Antimalarials Language: En Year: 2016 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Plasmodium falciparum / Drug Resistance / Artemisinins / Antimalarials Language: En Year: 2016 Type: Article