Vitamin D in newborns. A randomised controlled trial comparing daily and single oral bolus vitamin D in infants.
J Paediatr Child Health
; 53(2): 163-169, 2017 Feb.
Article
in En
| MEDLINE
| ID: mdl-27670154
ABSTRACT
AIM:
There are no published data to demonstrate the efficacy of bolus dose vitamin D in newborn infants. The study sought to evaluate this alternative approach of supplementation.METHODS:
This single centre, open randomised controlled trial was conducted from August 2013 to May 2014. It compared the efficacy and safety of daily (400 IU) versus a bolus dose (50 000 IU) of cholecalciferol in newborn infants of vitamin D deficient mothers. The primary outcome measure was the rate of 25 hydroxyvitamin D (25OHD) repletion-defined as 25OHD greater than 50 nmol/L. The secondary objective was determining safety using adjusted total serum calcium.RESULTS:
Of 70 eligible infants, 36 received a daily dose and 34 received a single high-dose cholecalciferol. Mean 25OHD in the bolus group (154 nmol/L, 95% confidence interval (CI) 131-177) was higher than the daily group (48 nmol/L, 95% CI 42-54) at 1-2 weeks of age. This was reversed at 3-4 months, (65 nmol/L, 95% CI 59-71) compared with the daily group (81 nmol/L, 95% CI 77-85). More infants in the single bolus group achieved vitamin D repletion (100 vs. 31%) at 1-2 weeks. By 3-4 months, both groups achieved similar vitamin D repletion rates (91 vs. 89%). Mean adjusted total serum calcium in the bolus group were normal at 1-2 weeks (2.73 mmol/L) and 3-4 months (2.55 mmol/L).CONCLUSION:
Single bolus dosing of 50 000 IU cholecalciferol achieves higher 25OHD repletion rates at 1-2 weeks of age compared with daily dosing, but repletion rates were similar by 3-4 months. There was no hypercalcaemia documented with single bolus dosing in this study.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Vitamin D
/
Vitamin D Deficiency
/
Administration, Oral
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Infant
/
Newborn
Country/Region as subject:
Oceania
Language:
En
Year:
2017
Type:
Article